Singapore skin booster guide: ingredients, treatment names and brands

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A clear guide to HA, PN/PDRN, bioremodelling and collagen stimulators: familiar brands, intended uses, evidence and recovery in Singapore.

You may want smoother skin, less dryness or a fresher look, yet find yourself hearing a string of names: HA, PN, skin booster, bioremodelling, Profhilo or Rejuran. Some describe ingredients, some describe a treatment approach, and others are brands. Knowing which is which makes it easier to follow a doctor's explanation and understand what change they have in mind.

This guide brings the main skin-quality injectables and closely related treatments together in one comparison. It explains the ingredients, names specific products and links to the sources behind the distinctions. If you are still exploring everyday care and procedures, our tired-looking-skin guide starts with that wider choice.

About this website: INNEA Aqua is an HA-based injectable for skin quality. Glo Pharma operates innea.com.sg and is its sole distributor in Singapore. We explain it alongside other products and identify the sources for each. Your doctor can assess which approach, if any, fits your skin.

INNEA Aqua packaging and syringes.
INNEA Aqua packaging and syringes.

What do you want the treatment to change?

You may like the shape of your face but wish the skin looked smoother or less dull. Or perhaps a hollow cheek is what makes you feel you look tired. Lines that appear when you frown raise another question. The same ingredient can be used in products designed for different jobs, so starting with the change you want is more useful than choosing from a brand list.

Three parts of a treatment description help put the names in order:

  • The goal: hydration, texture, wrinkles, a particular type of scar, fullness or softer expression lines.
  • The material: HA, purified DNA chains, a collagen-stimulating polymer or another substance.
  • The finished product and plan: its full name, formulation, intended use, treatment area and the way the doctor proposes to use it.

Labels such as skin booster, biorevitalisation and bioremodelling overlap. They describe aims or approaches; they do not establish that every product under the label works in the same way. Our skin booster, filler and bioremodelling comparison follows the visible changes those approaches are meant to address.

A Singapore comparison of ingredients and products

The table brings together the main skin-quality injectables, collagen-stimulating materials, fillers and wrinkle-relaxing medicines you may hear about in Singapore. The device links go to the exact HSA registration; the formulation links explain the ingredients. Medicine sources come from Singapore's National Drug Formulary, which publishes HSA-registered product details. Checked 13 October 2026.

Use the third column to see which concern to discuss. The table describes registered uses and product differences; your doctor will explain the likely result for you.

Different names, different meanings
Treatment type

What it aims to do

Material

What it contains

Product name

Which product is used

These labels describe different aspects of a treatment.

Material or formulation

Registered product examples

What this means for your choice in Singapore

Registration and formulation sources

Linear HA with trehalose

INNEA Aqua

Two sizes of water-holding HA chains with a sugar added to protect and stabilise the formula. Registered for ageing/photoageing changes including roughness, reduced radiance and wrinkles, and repair after superficial trauma such as acne and chickenpox scars. Listed areas: face, upper chest and hands.

HSA MDPR250815I0006; manufacturer formula

HA with amino acids and antioxidants

Teosyal PureSense Redensity I

A skin-quality formula for rehydration and ageing changes on the face, crow's feet, neck and neckline. Redensity II is a different product.

HSA DE0015591; Teoxane formula

HA with succinic acid

Xela Rederm 1.1%, 1.8% and 2.2%

Registered for moisturising and filling skin depressions from scarring or volume lost through lipoatrophy. Listed areas include forehead, eyelids, cheeks, chin and lower jaw. The version matters when discussing the area and amount of filling.

HSA MDPR260401X0003; formula in published research

Stabilised HA

Restylane Skinboosters Vital; Vital Lidocaine; Vital Light Lidocaine

Vital is registered for skin elasticity; the non-lidocaine record lists face, hands and upper arms. Vital Light's record includes moisture balance, structure and elasticity. These are the skin-quality products in a brand that also makes fillers.

HSA Vital DE0016808, Vital Lidocaine DE0016809, Vital Light Lidocaine DE0502928; formula instructions

Cross-linked HA

Juvéderm Volite; SKINVIVE by Juvéderm

Both Singapore records cover filling superficial depressions such as fine lines, with additional hydration and elasticity improvements. Both contain lidocaine to reduce pain during treatment.

HSA Volite DE0019006, SKINVIVE DE0509552; published formulation

Cross-linked HA with glycerol

Belotero Revive

HA with a water-attracting ingredient. Registered for early sun-damaged facial skin: dry skin, reduced elasticity and firmness, roughness and superficial fine lines.

HSA DE0506092; Merz formula instructions

Thermally stabilised hybrid HA

Profhilo; Profhilo Body

Often described as bioremodelling. The local record covers ageing-related skin changes and repair of superficial-trauma scars. Profhilo is listed for the face; Body for upper arms and abdomen.

HSA DE0504719; IBSA formula

A separate hybrid-HA formula

Profhilo Structura

Registered for skin depressions and ageing changes, including signs of lower-face fat loss and acne scars in the cheek region. This puts facial support and lost fullness into the discussion.

HSA DE0510727; IBSA formula

Polynucleotides (PN)

Rejuran, Rejuran I and Rejuran S; Plinest and Plinest fast

Purified DNA-chain gels used for skin-quality or repair aims. Rejuran's record covers face and neck tissue restoration; Plinest covers suppleness and acne scars; Plinest fast is listed for skin texture around the eyes.

HSA Rejuran DE0500702, Plinest DE0507900, fast DE0507899; PharmaResearch, Mastelli formulas

PN with HA

Rejuran HB Plus; Newest

HB Plus adds lidocaine and is registered for temporary improvement of adult crow's feet. Newest adds mannitol and is registered for moisture, elasticity and improvement of atrophic acne scars within a doctor's treatment plan.

HSA HB Plus DE0508363, Newest DE0508915; HB Plus formula, Newest formula

Poly-L-lactic acid (PLLA)

Sculptra

A biodegradable polymer with a collagen response that develops over time. Registered for depressed areas, wrinkles, folds, scars and signs of facial fat loss. Consider the gradual change and follow-up.

HSA DE0006297; Galderma product information

Poly-D,L-lactic acid (PDLLA)

AestheFill

A different polylactic-acid formulation, registered for temporary improvement of adult facial wrinkles and folds.

HSA DE0506247; REGEN formula

PDLLA with HA

Juvelook

Combines a collagen-stimulating polymer with HA. The Singapore record covers filling skin depressions and restoring or increasing soft-tissue volume.

HSA DE0507634; published formula

Calcium hydroxylapatite (CaHA) in a carrier gel

Radiesse; Radiesse (+) Lidocaine

Mineral particles used for soft-tissue support and volume. The standard product's local record also specifies a diluted preparation for moderate or severe upper-chest wrinkles. The doctor should explain the preparation for your goal.

HSA Radiesse DE0007895, (+) Lidocaine DE0500871; Merz formula

CaHA with HA and lidocaine

HArmonyCa Lidocaine

A hybrid filler registered to add facial soft-tissue volume in the midface, side of the face and jawline.

HSA MDPR260127A0001; Allergan formula

Polycaprolactone (PCL)

Ellansé S and M; Gouri

Another biodegradable polymer. Ellansé uses particles and is registered for facial wrinkles and ageing signs. Gouri uses a different, solubilised preparation and is registered for moderate or severe facial wrinkles and folds.

HSA Ellansé DE0501728, Gouri DE0507801; Sinclair formula, published Gouri description

HA fillers for shape and fullness

Restylane Defyne; Juvéderm Voluma with lidocaine; Teosyal PureSense Ultra Deep

Examples from the main HA filler brands. Used to add facial volume or fill deeper depressions. Ask about the precise version and area if your concern is a hollow cheek or facial shape.

HSA Defyne DE0018549, Voluma DE0009544, Ultra Deep DE0015589; KTPH clinical explanation

Botulinum toxin type A

Botox; Dysport; Xeomin

Prescription medicines that relax selected muscles to soften expression lines. Product-specific units and doses differ. The formulary links give Singapore-registered medicine details, including the approved wrinkle uses for each product.

NDF Botox SIN14203P, Dysport SIN15238P, Xeomin SIN14585P; HSA medicine register

Lidocaine is a local anaesthetic used to reduce pain. Mannitol and glycerol are water-attracting ingredients. A registered product may not be stocked by every clinic; ask for the full name of the version your doctor offers.

What makes one HA product different from another?

If dryness or roughness bothers you, the water-holding ability of hyaluronic acid (HA) helps explain why a doctor may discuss it. The formula then matters. Some HA chains remain linear, some are chemically joined together through cross-linking, and some products combine chain sizes through a different stabilising process. Those choices affect how the gel behaves, alongside concentration and added ingredients.

An HA product used for skin quality can address more than moisture alone. For INNEA Aqua, the Singapore HSA record lists ageing and photoageing changes including roughness, reduced radiance and wrinkles, plus dermal repair after superficial trauma such as acne and chickenpox scars. The listed areas are the face, décolleté—the upper chest—and hands.

INNEA Aqua's trehalose is a sugar added to protect and stabilise its HA. If you want to know how well the approach has been tested, our INNEA Aqua and HA evidence guide covers the formula tests and patient studies of similar HA injections.

Other added ingredients help distinguish the products in the table. Amino acids are building blocks of proteins; glycerol attracts water; succinic acid is studied as part of an HA combination. Their presence explains a formulation choice. The evidence for the finished product and the change you want remains more useful than a long ingredient list.

Are PN and PDRN the same thing?

If texture, fine lines or acne scars bother you, your doctor may mention PN, polynucleotides, or PDRN, polydeoxyribonucleotide. They are related DNA-derived materials. The terms are often used interchangeably in marketing, but they refer to different ingredients.

For your decision, ask which finished product the doctor means and what they expect it to change. The PN-only products in the table differ from those combining PN with HA. Some also have versions for particular areas, such as skin around the eyes. That is more useful than choosing from the abbreviation alone.

What does “collagen stimulation” mean for your decision?

If your skin is sagging or folds have become deeper, you may want more support as well as smoother texture. Collagen is a protein that gives skin structure. Some injectables encourage a collagen response that develops gradually, so the timing of the result matters.

PLLA, PDLLA, CaHA and PCL are different materials. Depending on the product, a plan can aim to fill a depression, add facial volume or improve support over time. Ask which of those changes you would actually notice, when to judge it and whether more visits are expected.

One practical difference is removal. The enzyme used to break down HA does not remove these other materials. A mixed HA-and-particle product also needs its own plan if you dislike the result. The filler guidance helps you weigh that commitment against a change in shape or fullness.

What if redness, pigmentation or dark under-eyes bother you most?

Point to the concern rather than assuming it is a skin-quality problem. A brown patch, visible blood vessels and a shadow from a hollow under-eye need different assessments. The US National Institutes of Health's rosacea guidance describes medical treatment and light or laser options for rosacea redness.

INNEA Aqua fits the conversation when roughness, wrinkles, reduced radiance or a superficial scar is also a concern. Its HSA registration describes those uses. For persistent redness or dark patches, the doctor should explain a separate treatment aimed at the cause.

HA with succinic acid has also been studied as an addition to rosacea care. A small study reported improvements in people continuing their usual topical treatment. If a doctor suggests that approach, ask how it would add to your existing care. The Xela Rederm registration in the table describes moisturising and filling uses.

What do other clinic labels mean?

Mesotherapy describes a method of giving small injections. Ask what is in them. Microneedling is a procedure using fine needles to create controlled small injuries in the skin; the needles themselves do not tell you which substance, if any, is used alongside it. PRP, platelet-rich plasma, is prepared from your own blood.

If you hear a newer term such as exosomes, ask about the exact product and route before considering it. HSA's public registers let you check a named health product. These treatments need a separate discussion about whether they are proven and suitable for your goal.

What recovery should you allow for?

Small injections can leave bumps, redness, tenderness or bruises. Filling and support treatments can also cause visible swelling, and some materials carry a risk of delayed lumps. Read our safety and downtime guide when weighing the treatment against work or an upcoming event.

Your doctor will explain recovery for the exact product, area and injection pattern, including any combined laser, peel or other injectable.

Talk to your doctor

You can use the table to follow the names that come up, but you do not have to choose a formula yourself. Every person's skin, goals and tolerance for recovery are different.

Your doctor can explain what is causing the change you see, which options fit, and the likely benefit, cost and recovery before you decide. The HSA advises that aesthetic injectables should be given by qualified medical practitioners.

If you need help comparing the treatment goals rather than the names, our booster, filler and bioremodelling guide starts there.

Sources and references

  1. Regulatory recordINNEA Aqua

    INNEA Aqua — Singapore medical device register

  2. ReferenceGeneral information

    manufacturer formula

  3. ReferenceGeneral information

    HSA DE0015591

  4. ReferenceGeneral information

    Teoxane formula

  5. ReferenceGeneral information

    HSA MDPR260401X0003

  6. ReferenceGeneral information

    formula in published research

  7. ReferenceGeneral information

    Vital DE0016808

  8. ReferenceGeneral information

    Vital Lidocaine DE0016809

  9. ReferenceGeneral information

    Vital Light Lidocaine DE0502928

  10. ReferenceGeneral information

    formula instructions

  11. ReferenceGeneral information

    Volite DE0019006

  12. ReferenceGeneral information

    SKINVIVE DE0509552

  13. ReferenceGeneral information

    published formulation

  14. ReferenceGeneral information

    HSA DE0506092

  15. ReferenceGeneral information

    Merz formula instructions

  16. ReferenceGeneral information

    HSA DE0504719

  17. ReferenceGeneral information

    IBSA formula

  18. ReferenceGeneral information

    HSA DE0510727

  19. ReferenceGeneral information

    IBSA formula

  20. ReferenceGeneral information

    Rejuran DE0500702

  21. ReferenceGeneral information

    Plinest DE0507900

  22. ReferenceGeneral information

    fast DE0507899

  23. ReferenceGeneral information

    PharmaResearch

  24. ReferenceGeneral information

    Mastelli

  25. ReferenceGeneral information

    HB Plus DE0508363

  26. ReferenceGeneral information

    Newest DE0508915

  27. ReferenceGeneral information

    HB Plus formula

  28. ReferenceGeneral information

    HSA DE0006297

  29. ReferenceGeneral information

    Galderma product information

  30. ReferenceGeneral information

    HSA DE0506247

  31. ReferenceGeneral information

    REGEN formula

  32. ReferenceGeneral information

    HSA DE0507634

  33. ReferenceGeneral information

    published formula

  34. ReferenceGeneral information

    Radiesse DE0007895

  35. ReferenceGeneral information

    (+) Lidocaine DE0500871

  36. ReferenceGeneral information

    Merz formula

  37. ReferenceGeneral information

    HSA MDPR260127A0001

  38. ReferenceGeneral information

    Allergan formula

  39. ReferenceGeneral information

    Ellansé DE0501728

  40. ReferenceGeneral information

    Gouri DE0507801

  41. ReferenceGeneral information

    Sinclair formula

  42. ReferenceGeneral information

    published Gouri description

  43. ReferenceGeneral information

    Defyne DE0018549

  44. ReferenceGeneral information

    Voluma DE0009544

  45. ReferenceGeneral information

    Ultra Deep DE0015589

  46. ReferenceGeneral information

    KTPH clinical explanation

  47. ReferenceGeneral information

    Botox SIN14203P

  48. ReferenceGeneral information

    Dysport SIN15238P

  49. ReferenceGeneral information

    Xeomin SIN14585P

  50. ReferenceGeneral information

    HSA medicine register

  51. ReferenceGeneral information

    rosacea guidance

  52. ReferenceGeneral information

    HSA advises that aesthetic injectables should be given by qualified medical practitioners